How do cells transport ingested food items or viruses such as the coronavirus SARS-CoV2 to the cellular stomach, the lysosome, and break them down? This was the question behind a recent study of a research team led by scientists from Osnabrück Biology. Using state-of-the-art microscopy technology, they unravelled the 3D structure of the HOPS complex, which plays a central role in this process. The study was published in the renowned scientific journal eLife.
Publication:
Shvarev, D.; Schoppe, J.; König, C.; Perz, A.; Füllbrunn, N.; Kiontke, S.; Langemeyer, L.; Januliene, D.; Schnelle, K.; Kümmel, D.; Fröhlich, F.; Moeller, A. & Ungermann, C. (2022): Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery. eLife.
