Cellular dynamics at the highest resolution: Scientists at CellNanOs develop new microscope

Scientists at the iBiOs and the Biophysics division have developed a correlative microscope method that allows the simultaneous imaging of molecular interactions and their nano-environment in living cells with very high temporal and spatial resolution.

The new method enables, for example, the analysis of immune receptor dynamics on the cell, which move in complex membrane systems that are in turn linked to the cytoskeleton (actin). The researchers led by Prof. Dr. Jacob Piehler and Dr. Rainer Kurre combined two high-resolution microscopy techniques to create a unique new system. They have now presented their new method in the renowned journal “Nature Communications”.

 

Publication:

Winkelmann, H.; Richter, C. P.; Eising, J.; Piehler, J. & Kurre, R. (2024):  Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane. Nature Communications.

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