Publications

 A strategy to design protein-based antagonists against type I cytokine receptors

Ullrich T, Klimenkova O, Pollmann C, Lasram A, Hatskovska V, Maksymenko K, Milijaš-Jotić M, Schenk L, Lengerke C, Hartmann MD, Piehler J, Skokowa J, ElGamacy M (2024) PLoS Biol 22(11):e3002883

 Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy

Zoler E, Meyer T, Bellón JS, Mönnig M, Sun B, Piehler J, Schreiber G (2024) Sci Signal 17(863):eadl1892.

 Structure of the yeast ceramide synthase

Schäfer JH, Clausmeyer L, Körner C, Esch BM, Wolf VN, Sapia J, Ahmed Y, Walter S, Vanni S, Januliene D, Moeller A, Fröhlich F (2024) Nat Struct Mol Biol 32(3):441-449.

 Complex sphingolipid profiling and identification of an inositol-phosphorylceramide synthase in Dictyostelium discoideum

Listian SA, Mazur AC, Kol M, Ufelmann E, Eising S, Fröhlich F, Walter S, Holthuis JCM, Barisch C (2024) iScience 27(9):110609.

 An anatomical atlas of Drosophila melanogaster — the wild-type

Jürgens KJ, Drechsler M, Paululat A (2024) Genetics 228(2):iyae129.

 Gasdermin D cysteine residues synergistically control its palmitoylation-mediated membrane targeting and assembly

Margheritis E, Kappelhoff S, Danial J, Gehle N, Kohl W, Kurre R, González Montoro A, Cosentino K (2024) EMBO J 43(19):4274-4297

 The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm protein

Körner C, Schäfer JH, Esch BM, Parey K, Walter S, Teis D, Januliene D, Schmidt O, Moeller A, Fröhlich F (2024) Cell Rep 43(8):114627

 Marvels of spiny mouse regeneration: cellular players and their interactions in restoring tissue architecture in mammals

Tomasso A, Disela V, Longaker MT, Bartscherer K (2024) Curr Opin Genet Dev 87:102228

 Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane

Winkelmann H, Richter CP, Eising J, Piehler J, Kurre R (2024) Nature communications, 15(1), 5813

 Structure of the endosomal CORVET tethering complex

Shvarev D, König C, Susan N, Langemeyer L, Walter S, Perz A, Fröhlich F, Ungermann C, Moeller A (2024) Nat Commun 15(1):5227.

 Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling

Caveney NA, Rodriguez GE, Pollmann C, Meyer T, Borowska MT, Wilson SC, Wang N, Xiang X, Householder KD, Tao P, Su LL, Saxton RA, Piehler J, Garcia KC (2024) Mol Cell 84(10):1995-2005.e7

 Adamantylglycine as a hgh-affinity peptide label for membrane transport monitoring and regulation

Pramod M, Alnajjar MA, Schöpper SN, Schwarzlose T, Nau WM, Hennig A (2024) Chem. Commun. Advance article

 Cellular uptake of cell-penetrating peptides activated by amphiphilic p-sulfonatocalix[4]arenes

Huang C, Liu YC, Oh H, Guo DS, Nau WM, Hennig A (2024) Chem. Eur. J. e202400174.

 Destruction of the brush border by Salmonella enterica sv. Typhimurium subverts resorption by polarized epithelial cells

Felipe-López A, Hansmeier N, Hensel M (2024) Front Microbiol 15:1329798.

 Yeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase

Klössel S, Zhu Y, Amado L, Bisinski DD, Ruta J, Liu F, González Montoro A (2024) EMBO J 43(9):1870-1897

 The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes

Füllbrunn N, Nicastro R, Mari M, Griffith J, Herrmann E, Rasche R, Borchers AC, Auffarth K, Kümmel D, Reggiori F, De Virgilio C, Langemeyer L, Ungermann C (2024) J Cell Biol 223(6):e202305038

 Rapid in-EPON CLEM: Combining fast and efficient labeling of self-labeling enzyme tags with EM-resistant Janelia Fluor dyes and StayGold

Franzkoch R, Wilkening S, Liss V, Holtmannspötter M, Kurre R, Psathaki OE, Hensel M (2024) Heliyon 10(7):e28055

 Generation of a TMEM43 knockout human induced pluripotent stem cell line (HDZi003-A-1) using CRISPR/Cas9

Ratnavadivel S, Dammeier J, Gaertner A, de Toledo MAS, Zenke M, Gummert J, Bloch Rasmussen T, Klinke N, Jürgens K, Meyer H, Paululat A, Milting H (2024) Stem Cell Res 76:103354.

 New insights into Gasdermin D pore formation

Kappelhoff S, Margheritis EG, Cosentino K (2024) Biochem Soc Trans 52(2):681-692

 Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Gardner S, Jin Y, Fyfe PK, Voisin TB, Bellón JS, Pohler E, Piehler J, Moraga I, Bubeck D (2024) Nat Commun 15(1):2071

 Functional conservation of the small GTPase Rho5/Rac1—A tale of yeast and men

Bischof L, Schweitzer F, Heinisch JJ (2024) Cells 13(6):472.

 Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction

Pinzi L, Conze C, Bisi N, Torre GD, Soliman A, Monteiro-Abreu N, Trushina NI, Krusenbaum A, Dolouei MK, Hellwig A, Christodoulou MS, Passarella D, Bakota L, Rastelli G, Brandt R (2024)  Nat Commun 15(1):1679

 Bright individuals: Applications of fluorescent protein-based reporter systems in single-cell cellular microbiology

Schulte M, Grotheer L, Hensel M (2024) Mol Microbiol 121:605–617.

 Tracing the substrate translocation mechanism in P-glycoprotein

Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q (2023) Elife 12:RP90174.

 Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC (2023) Cell 186(19):4189-4203.e22.

 Mechanisms of nonvesicular ceramide transport

Clausmeyer L, Fröhlich F (2023) Contact (Thousand Oaks) 6:25152564231208250.

 Why kiss-and-hop explains that tau does not stabilize microtubules and does not interfere with axonal transport (at physiological conditions)

Bakota L, Brandt R (2023) Cytoskeleton (Hoboken) 81(1):47-52.

 Conformational variability of cyanobacterial ChlI, the AAA+ motor of magnesium chelatase involved in chlorophyll biosynthesis

Shvarev D, Scholz AI, Moeller A (2023) mBio 14(5)

 The dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formation

Arlt H, Raman B, Filali-Mouncef Y, Hu Y, Leytens A, Hardenberg R, Guimarães R, Kriegenburg F, Mari M, Smaczynska-de Rooij II, Ayscough KR, Dengjel J, Ungermann C, Reggiori F (2023) Biol. Chem. 299(5):104712.

 First-row d⁶ metal complex enables photon upconversion and initiates blue light-dependent polymerization with red light

Wang C, Wegeberg C, Wenger OS (2023) Angew Chem Int Ed Engl. 62(43):e202311470.

 Dual-color real-time chemosensing of a compartmentalized reaction network involving enzyme-induced membrane permeation of peptides

Jiang R, Nilam M, Hennig A, Nau WM (2023) Adv. Mater. 36(4):2306922

 ER-dependent membrane repair of mycobacteria-induced vacuole damage

Anand A, Mazur A-C, Rosell-Arevalo P, Franzkoch R, Breitsprecher L, Listian SA, Hüttel SV, Müller D, Schäfer DG, Vormittag S, Hilbi H, Maniak M, Gutierrez MG, Barisch C (2023) mBio 14(5):e0094323.

 Topographical surface patterning with block copolymer stamps

Guo L, Steinhart M (2023) ScienceDirect, Applied Surface Science(639)

 Different tether proteins of the same membrane contact site affect the localization and mobility of each other

Amado L, Cogan AP, González Montoro A (2023) J Cell Sci 136(13):jcs260786

 Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation

Borchers AC, Janz M, Schäfer JH, Moeller A, Kümmel D, Paululat A, Ungermann C, Langemeyer L (2023) Proc Natl Acad Sci U S A 120(30):e2303750120. 

 Drosophila collagens in specialised extracellular matrices

Reinhardt M, Drechsler M, Paululat A (2023) Biol Chem. 404(5):535-550.

 The role of lysosomes in lipid homeostasis

Fröhlich F, González Montoro A (2023) Biol. Chem. 404(5):455-465.

 Molecular determinants of protein half-life in chloroplasts with focus on the Clp protease system

Winckler LI, Dissmeyer N (2023) Biol. Chem. 404(5):499-511.

 Determinants of synergistic cell-cell interactions in bacteria

Pauli B, Ajmera S, Kost C (2023) Biol. Chem. 404(5):499-511

 Pore-forming proteins: from pore assembly to structure by quantitative single-molecule imaging

Margheritis E, Kappelhoff S, Cosentino K (2023) Int J Mol Sci 24(5):4528.

 Manipulation of microvillar proteins during Salmonella enterica invasion results in brush border effacement and actin remodeling

Felipe-López A, Hansmeier N, Danzer C, Hensel M (2023) Front Cell Infect Microbiol 13:1137062.

 Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Tsirigotaki A, Dansercoer A, Verschueren KHG, Marković I, Pollmann C, Hafer M, Felix J, Birck C, Van Putte W, Catteeuw D, Tavernier J, Fernando Bazan J, Piehler J, Savvides SN, Verstraete K (2023) Nat. Struct. Mol. Biol. 30:551–563.

 The dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formationThe dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formation

Arlt H, Raman B, Filali-Mouncef Y, Hu Y, Leytens A, Hardenberg R, Guimarães R, Kriegenburg F, Mari M, Smaczynska-de Rooij II, Ayscough KR, Dengjel J, Ungermann C, Reggiori F (2023) J Biol Chem 13:104712.

 Special issue on “Cytoskeletal proteins in health and neurodegenerative disease: Concepts and methods”

Brandt R, Götz J (2023) Brain Res Bull 198:50-52.

 Real-time growth kinetics analysis of macromolecular assemblies in cells with single molecule resolution

Danial JSH, Jenner A, Garcia-Saez AJ, Cosentino K (2023) J Phys Chem A 127(15):3490-3496

 Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation

Arroum T, Borowski MT, Marx N, Schmelter F, Scholz M, Psathaki OE, Hippler M, Enriquez JA, Busch KB (2023) Biol. Chem. 404(5):399-415.

 An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys)

Tomasso A, Koopmans T, Lijnzaad P, Bartscherer K, Seifert AW (2023) Sci Adv 9(17):eadf2331.

 When crystals flow

Tu CH, Steinhart M, Berger R, Kappl M, Butt HJ, Floudas G (2023) Sci. Adv. 9(19):eadg8865

 Early endosomes act as local exocytosis hubs to repair endothelial membrane damage

Raj N, Greune L, Kahms M, Mildner K, Franzkoch R, Psathaki OE, Zobel T, Zeuschner D, Klingauf J, Gerke V (2023) Adv Sci (Weinh) e2300244.

 Yeast Svf1 binds ceramides and contributes to sphingolipid metabolism at the ER cis-Golgi interface

Limar S, Körner C, Martínez-Montañés F, Stancheva VG, Wolf VN, Walter S, Miller EA, Ejsing CS, Galassi VV, Fröhlich F (2023) J Cell Biol 222(5):e202109162.

 Molecular changes in hippocampal energy metabolism in mice selectively bred for extremes in stress reactivity: Relevance of mitochondrial dysfunction for affective disorders

Rappeneau V, Koti P, Wilmes L, Widner-Andrae R, Busch K, Touma C (2023) Eur J Neurosci. 58(2):2579-2602.

 Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Nguyen PD, Gooijers I, Campostrini G, Verkerk AO, Honkoop H, Bouwman M, de Bakker DEM, Koopmans T, Vink A, Lamers GEM, Shakked A, Mars J, Mulder AA, Chocron S, Bartscherer K, Tzahor E, Mummery CL, de Boer TP, Bellin M, Bakkers J (2023) Science 380(6646):758-764.

 Yck3 casein kinase-mediated phosphorylation determines Ivy1 localization and function at endosomes and the vacuole

Grziwa S, Schäfer JH, Nicastro R, Arens A, De Virgilio C, Fröhlich F, Moeller A, Gao J, Langemeyer L, Ungermann C (2023) J Cell Sci jcs.260889.

 Flagella-mediated cytosolic motility of Salmonella enterica Paratyphi A aids in evasion of xenophagy but does not impact egress from host cells

Scharte F, Franzkoch R, Hensel M (2023) Mol Microbiol 00, 1–18.

 Multiple tethers of organelle contact sites are involved in α-synuclein toxicity in yeast

Del Vecchio M, Amado L, Cogan AP, Meert E, Rosseels J, Franssens V, Govers SK, Winderickx J, Montoro AG (2023) Mol Biol Cell 34(8):ar84

 Differentiation and function of cardiac valves in the adult Drosophila heart

Meyer C, Drechsler M, Meyer H, Paululat A (2023) J Exp Biol jeb.245839.

 Single-molecule fluorescent in situ hybridization (smFISH) on whole-mount planarians

Roovers EF, Bartscherer K (2023) Schmidtea Mediterranea 2680:93–106.

 Click-functionalization of silanized carbon nanotubes: from inorganic heterostructures to biosensing nanohybrids

Manoharan G, Bösel P, Thien J, Holtmannspötter M, Meingast L, Schmidt M, Eickmeier H, Haase M, Maultzsch J, Steinhart M, Wollschläger J, Palma M, Meyer C (2023) Molecules 28(5):2161.

 Dispersible SnO2 :Sb and TiO2 nanocrystals after calcination at high temperature

Klein J, Philippi M, Alarslan F, Jähnichen T, Enke D, Steinhart M, Haase M (2023) Small 19(10):e2207674.

 Single molecule analyses reveal dynamics of Salmonella translocated effector proteins in host cell endomembranes

Göser V, Sander N, Schulte M, Scharte F, Franzkoch R, Liss V, Psathaki OE, Hensel M (2023) Nat Commun 14(1):1240.

 Setting up a data management infrastructure for bioimaging

Kunis S, Bernhardt K, Hensel M (2023) Biol. Chem. 404(5):433-439.

 Membrane damage and repair: a thin line between life and death

Barisch C, Holthuis J, Cosentino C (2023) Biol. Chem. 404(5):467-490.

 The role of lysosomes in lipid homeostasis

Fröhlich F, González Montoro A (2023) Biol. Chem. 404(5):455-465.

 Targeting of the Mon1-Ccz1 Rab guanine nucleotide exchange factor to distinct organelles by a synergistic protein and lipid code

Herrmann E, Langemeyer L, Auffarth K, Ungermann C, Kümmel D (2023) J Biol Chem 102915.

 Computational resolution in single molecule localization - impact of noise level and emitter density

Hockmann M, Kunis S, Kurre R (2023) Biol. Chem. 404(5):427-43

 Reversible live-cell labeling with retro-engineered HaloTags enables long-term high- and super-resolution imaging

Holtmannspötter M, Wienbeuker E, Dellmann T, Watrinet I, Garcia Saez AJ, Johnsson K, Kurre R, Piehler J (2023) Angew Chem Int Ed Engl. 62(18):e202219050

 Drosophila collagens in specialised extracellular matrices

Reinhardt M, Drechsler M, Paululat A (2023) Biol. Chem. 404(5):535-550.

 Lattice light-sheet microscopy and evaluation of dendritic transport in cultured hippocampal tissue reveal high variability in mobility of the KIF1A motor domain and entry into dendritic spines

Rierola M, Trushina NI, Holtmannspötter M, Kurre R, Bakota L (2023) Brain Research Bulletin 149:13-22.

 Neuronal stress granules as dynamic microcompartments: current concepts and open questions

Söhnel AC, Brandt R (2023) Biol. Chem. 404(5):491-498

 Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters

Saltukoglu D, Özdemir B, Holtmannspötter M, Reski R, Piehler J, Kurre R, Reth M (2023) EMBO J e112030.

 Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy

Yang X, Nishimiya D, Löchte S, Jude KM, Borowska M, Savvides CS, Dougan M, Su L, Zhao X, Piehler J, Garcia KC (2023) Nat. Biotechnol. 41:932–943.

 STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation

Zanin N, Viaris de Lesegno C, Podkalicka J, Meyer T, Gonzalez Troncoso P, Bun P, Danglot L, Chmiest D, Urbé S, Piehler J, Blouin CM, Lamaze C (2023) Nat Cell Biol. 25:425–438

 Trichome transcripts as efficiency control for synthetic biology and molecular farming

Becker R, Görner C, Reichman P, Dissmeyer N. (2022) Methods Mol Biol. 2379:265-276.

 The intracellular distribution of the small GTPase Rho5 and its dimeric guanidine nucleotide exchange factor Dck1/Lmo1 determine their function in oxidative stress response

Bischof L, Schweitzer F, Sterk CC, Heinisch JJ. (2022) Int J Mol Sci. 23(14):7896.

 IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. (2022) Sci Immunol. 7(78):eade5686

 Preparation of drosophila tissues and organs for transmission electron microscopy

Psathaki OE, Paululat A. (2022) Methods Mol Biol. 2540:361-385

 Common patterns of hydrolysis initiation in P-loop fold nucleoside triphosphatases

Kozlova MI, Shalaeva DN, Dibrova DV, Mulkidjanian AY (2022) Biomolecules 12(10), 1345

 Common mechanism of activated catalysis in P-loop fold nucleoside triphosphatases—United in diversity

Kozlova MI, Shalaeva DN, Dibrova DV, Mulkidjanian AY (2022) Biomolecules 12(10), 1346

 Biofunctional nanodot arrays in living cells uncover synergistic co-condensation of Wnt signalodroplets

Philippi M, Richter CP, Kappen M, Watrinet I, Miao Y, Runge M, Jorde L, Korneev S, Holtmannspötter M, Kurre R, Holthuis JCM, Garcia KC, Plückthun A, Steinhart M, Piehler J, You C (2022) Small e2203723.

 The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells

Galazzo L, Meier G, Januliene D, Parey K, De Vecchis D, Striednig B, Hilbi H, Schäfer LV, Kuprov I, Moeller A,  Bordignon E, Seeger MA (2022) Sci Adv. 8(41):eabn6845.

 Super-resolution imaging and quantitative analysis of microtubule arrays in model neurons show that epothilone D increases the density but decreases the length and straightness of microtubules in axon-like processes

Conze C, Trushina NI, Holtmannspötter M, Rierola M, Attanasio S, Bakota L, Piehler J, Brandt R (2022) Brain Res Bull. 190:234-243.

 Reactive additive capillary stamping with double network hydrogel-derived aerogel stamps under solvothermal conditions

Alarslan F, Frosinn M, Ruwisch K, Thien J, Jähnichen T, Eckert L, Klein J, Haase M, Enke D, Wollschläger J, Beginn U, Steinhart M (2022) ACS Appl. Mater. Interfaces 14(39):44992–45004

 Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

Sokoya T, Parolek J, Foged MM, Danylchuk DI, Bozan M, Sarkar B, Hilderink A, Philippi M, Botto LD, Terhal PA, Mäkitie O, Piehler J, Kim Y, Burd CG, Klymchenko AS, Maeda K, Holthuis JCM. (2022) Elife. 11:e79278.

 Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery

Shvarev D, Schoppe J, König C, Perz A, Füllbrunn N, Kiontke S, Langemeyer L, Januliene D, Schnelle K, Kümmel D, Fröhlich F, Moeller A, Ungermann C. (2022) Elife 11:e80901. 

 Preparation of drosophila tissues and organs for transmission electron microscopy

Psathaki OE, Paululat A. (2022) Methods Mol Biol. 2540:361-385.

 Proton-gradient-driven sensitivity enhancement of liposome-encapsulated supramolecular chemosensors

Nilam M, Karmacharya S, Nau WM, Hennig A. (2022) Angew Chem Int Ed Engl. 61(35):e202207950.

 Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response

Shih HP, Ding JY, Sotolongo Bellón J, Lo YF, Chung PH, Ting HT, Peng JJ, Wu TY, Lin CH, Lo CC, Lin YN, Yeh CF, Chen JB, Wu TS, Liu YM, Kuo CY, Wang SY, Tu KH, Ng CY, Lei WT, Tsai YH, Chen JH, Chuang YT, Huang JY, Rey FA, Chen HK, Chang TW, Piehler J, Chi CY, Ku CL. (2022) J Exp Med. 219(9):e20212126.

 Densely methylated DNA traps Methyl-CpG Binding Domain protein 2 but permits free diffusion by Methyl-CpG Binding Domain protein 3

Leighton GO, Irvin EM, Kaur P, Liu M, You C, Bhattaram D, Piehler J, Riehn R, Wang H, Pan H, Williams DC Jr. (2022) Biol Chem. 26:102428.

 An alliance between lipid transfer proteins and scramblases for membrane expansion

Holthuis JCM, Jahn H, Menon AK, Mizushima N. (2022) Fac Rev. 11:22

 Identification of a thyroid hormone binding site in Hsp90 with implications for its interaction with thyroid hormone receptor beta

Fan L, Kishore A, Jansen-Olliges L, Wang D, Stahl F, Psathaki OE, Harre J, Warnecke A, Weder J, Preller M, Zeilinger C. (2022)  ACS Omega. 7(33):28932-28945.

 Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis

Bisinski DD, Gomes Castro I, Mari M, Walter S, Fröhlich F, Schuldiner M, González Montoro A. (2022) J Cell Biol. 221(8):e202103048.

 Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides

Schiemann R, Buhr A, Cordes E, Walter S, Heinisch JJ, Ferrero P, Milting H, Paululat A, Meyer H (2022) Nat Commun. 13(1):4420

 A Drosophila melanogaster model for TMEM43 related arrhythmogenic right ventricular cardiomyopathy type 5

Klinke N, Meyer H, Ratnavadivel S, Reinhardt M, Heinisch JJ, Malmendal A, Milting H, Paululat A (2022) Cell Mol Life Sci. 79(8):444

 Organizing structural principles of the interleukin-17 ligand-receptor axis

Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC. (2022) Nature, 609:622–629.

 Vesicle transport: Exocyst follows PIP2 to tether membranes

Langemeyer L, Ungermann C. (2022) Curr Biol. 32(13):R748-R750.

 The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity

Gao J, Nicastro R, Péli-Gulli M-P, Grziwa S, Chen Z, Kurre R, Piehler J, De Virgilio C, Fröhlich F, Ungermann C (2022) J Cell Biol  221(5):e202109084.

 Dissociation of β2m from MHC class I triggers formation of noncovalent, transient heavy chain dimers

Dirscherl C, Löchte S, Hein Z, Kopicki JD, Harders AR, Linden N, Karner A, Preiner J, Weghuber J, Garcia-Alai M, Uetrecht C, Zacharias M, Piehler J, Lanzerstorfer P, Springer S (2022) J Cell Sci. jcs.259498

 The yeast LYST homolog Bph1 is a Rab5 effector and prevents Atg8 lipidation at endosomes

Vargas Duarte P,  Hardenberg R, Mari M, Walter S, Reggiori F, Fröhlich F, González Montoro A, Ungermann C (2022) J Cell Sci. 135(8):jcs259421

 Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport

Conze C, Rierola M, Trushina NI, Peters M, Janning D, Holzer M, Heinisch JJ, Arendt T, Bakota L, Brandt R. (2022) Mol Psychiatry. 

 Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to intracellular S. Typhimurium

Cohen H, Hoede C, Scharte F, Coluzzi C, Cohen E, Shomer I, Mallet L, Holbert S, Serre RF,  Schiex T, Virlogeux-Payant I, Grassl GA, Hensel M, Chiapello H, Gal-Mor O (2022) PLoS Pathog. 18(4):e1010425.

 A lysosomal biogenesis map reveals the cargo spectrum of yeast vacuolar protein targeting pathways

Eising S, Esch B, Wälte M, Vargas Duarte P, Walter S, Ungermann C, Bohnert M, Fröhlich F (2022) J Cell Biol. 221(4):e202107148.

 Ca²⁺-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair

Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, Südhoff E, Hilderink A, Imlau M, Clarke CJ, Hensel M, Burd CG, Holthuis JCM (2022) 

 Confocal real-time analysis of cutaneous platelet recruitment during immune-complex-mediated inflammation

Currie SM, Stegmeyer RI, Mildner K, Breitsprecher L, Zeuschner D, Psathaki OE, Schäfer K, Wilkens M, Volkery S, Nieswandt B, Vestweber D. (2022) J Invest Dermatol.  31:S0022-202X(22)00254-8.

 Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria

Gohrbandt M, Lipski A, Grimshaw JW, Buttress JA, Baig Z, Herkenhoff B, Walter S, Kurre R, Deckers-Hebestreit G, Strahl H. (2022) EMBO J. e109800.

 Compartmentation and functions of sphingolipids

Körner C, Fröhlich F (2022) Curr Opin Cell Biol. 74:104-111.

 Monitoring and quantification of the dynamics of sress granule components in living cells by fluorescence decay after photoactivation

Söhnel AC, Trushina NI, Brandt R (2022) Methods Mol Biol. 2428:243-259.

 Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation

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 Frozen motion: how cryo-EM changes the way we look at ABC transporters

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 Cationic ordering and its influence on the magnetic properties of co-rich cobalt ferrite thin films prepared by reactive solid phase epitaxy on Nb-doped SrTiO3(001)

Thien J, Bahlmann J, Alexander A, Ruwisch K, Rodewald J, Pohlmann T, Hoppe M, Alarslan F, Steinhart M, Altuncevahir B, Shafer P,  Meyer C, Bertram F, Wollschläger J, Küpper K (2021) Materials (Basel) 15(1):46.

 NIR-to-NIR imaging: extended excitation up to 2.2 μm using harmonic nanoparticles with a tunable hIGh EneRgy (TIGER) widefield microscope

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Koopmans T, van Beijnum H, Roovers EF, Tomasso A, Malhotra D, Boeter J, Psathaki OE, Versteeg D, van Rooij E, Bartscherer K (2021) NPJ Regen Med  6(1):78.

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Guo L, Klein J, Thien J, Philippi M, Haase M, Wollschläger J, Steinhart M (2021) ACS Appl Mater Interfaces 13(41):49567-49579.

 Single cell analyses reveal distinct adaptation of typhoidal and non-typhoidal Salmonella enterica serovars to intracellular lifestyle

Reuter T, Scharte F, Franzkoch R, Liss V, Hensel M (2021) Plos Pathog 17(6):e1009319.

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 Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole

Gonzáles Montoro A, Vargas Duarte P, Auffarth K, Walter S, Fröhlich F, Ungermann C (2021) Mol Biol Cell  32(22) mbc.E21-05-0227.

 IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs

Shemesh M, Lochte S, Piehler J, Schreiber G (2021) Sci Signal  14(710):eabe4627.

 Metabolic dissimilarity determines the establishment of cross-feeding interactions in bacteria

Giri S, Oña L, Waschina S, Shitut S, Yousif G, Kaleta C, Kost C (2021) Curr Biol  S0960-9822(21)01408-1.

 Dendrite tapering actuates a self-organizing signaling circuit for stochastic filopodia initiation in neurons

Mancinelli G, Lamparter L, Nosov G, Saha T,  Pawluchin A, Kurre R, Rasch C, Ebrahimkutty M, Klingauf J, Galic M (2021) Proc Natl Acad Sci U S A  118(43):e2106921118.

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Schoppe J, Schubert E, Apelbaum A, Yavavli E, Birkholz O, Stephanowitz H, Han Y, Perz A, Hofnagel O, Liu F, Piehler J, Raunser S, Ungermann C (2021) J Biol Chem  101334.

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Alnajja MA, Nau WM, Hennig A (2021) Org Biomol Chem 19(39):8521-8529.

 Diffraction-unlimited photomanipulation at the plasma membrane via specifically targeted upconversion nanoparticles

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 MDEmic: a metadata annotation tool to facilitate management of FAIR image data in the bioimaging community

Kunis S, Hänsch S, Schmidt C, Wong F, Strambio-De-Castillia C, Weidtkamp-Peters S (2021) Nature Methods  18:1416–1417.

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 Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi

Schoppe J, Schubert E, Apelbaum A, Yavavli E, Birkholz O, Stephanowitz H, Han Y, Perz A, Hofnagel O, Liu F, Piehler J, Raunser S, Ungermann C (2021) J Biol Chem 297(5):101334.

 The small GTPase KlRho5 responds to oxidative stress and affects cytokinesis

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 Obligate cross-feeding expands the metabolic niche of bacteria

Oña L, Giri G, Avermann N, Kreienbaum M, Thormann KM, Kost C (2021) Nat Ecol Evol  5(9):1224-1232.

 Who’s in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond

Borchers AC, Langemeyer L,  Ungermann C (2021) J Cell Biol  220(9):e202105120.

 Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization

Stüber JC, Richter CP, Sotolongo Bellón J, Schwill M, König I, Schuler B, Piehler J, Plückthun A (2021) Commun Biol 4(1):762.

 In-vivo tracking of harmonic nanoparticles: a study based on a TIGER widefield microscope

Vittadello L, Kijatkin C, Klenen J, Dzikonski D, Kömpe K, Meyer C, Paululat A, Imlau M (2021) Optical Materials Express  11:1953-1969.

 Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

Kast F, Schwill M, Stüber JC, Pfundstein S, Nagy-Davidescu G, Rodríguez JMM, Seehusen F, Richter CP, Honegger A, Hartmann KP, Weber TG, Kroener F, Ernst P, Piehler J, Plückthun A (2021) Nat Commun 12(1):3790.

 Evaluation of DIBMA nanoparticles of variable size and anionic lipid content as tools for the structural and functional study of membrane proteins

Voskoboynikova N, Margheritis EG, Kodde F, Rademacher M, Schowe M, Budke-Gieseking A, Psathaki OE, Steinhoff HJ, Cosentino K (2021) Biochim Biophys Acta Biomembr  1863(6):183588.

 Lipid dynamics in diisobutylene-maleic acid (DIBMA) lipid particles in presence of sensory rhodopsin II

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 The protected physiological state of intracellular Salmonella enterica persisters reduces host cell-imposed stress

Schulte M, Olschewski K, Hensel M (2021) Commun Biol  4(1):520.

 Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

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 Biofunctionalization of carbon nanotubes for reversible site-specific protein immobilization

Jorde L, Li Z, Pöppelwerth A, Piehler J, You C, Meyer C (2021) Journal of Applied Physics  129:094302.

 Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

Wilmes S, Jeffrey PA, Martinez-Fabregas J, Hafer M, Fyfe PK, Pohler E, Gaggero S, López-García M, Lythe G, Taylor C, Guerrier T, Launay D, Mitra S, Piehler J, Molina-París C, Moraga I (2021) Elife  10:e66014.

 TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D (2021) Mol  Cell  30:S1097-2765(21)00324-5.

 Fluorescent protein-based reporters reveal stress response of intracellular Salmonella enterica at level of single bacterial cells

Schulte M, Olschewski K, Hensel M (2021) Cell Microbiol  23(3):e13293.

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Chavarin CA, Hardt E, Gruessing S, Skibitzki O, Costina I, Spirito D, Seifert W, Klesse W, Manganelli CL, You C, Flesch J, Piehler J, Missori M, Baldassarre L, Witzigmann B, Capellini G (2021) Opt Express  29(5):7680-7689.

 Correlative light and scanning electron microscopy to study interactions of Salmonella enterica with polarized epithelial cell monolayers

Kommnick C, Hensel M (2021) Methods Mol Biol J2182:103-115.

 Three-dimensional interfacing of cells with hierarchical silicon nano/microstructures for midinfrared interrogation of in situ captured proteins

Flesch J, Bettenhausen M, Kazmierczak M, Klesse WM, Skibitzki O, Psathaki OE, Kurre R, Capellini G, Guha S, Schroeder T, Witzigmann B, You C, Piehler J (2021) ACS Appl Mater Interfaces.

 Self-labeling enzyme tags for translocation analyses of Salmonella effector proteins

Göser V, Hensel M (2021) Methods Mol Biol 2182:67-82.

 Short photoswitchable ceramides enable optical control of apoptosis

Morstein J, Kol M, Novak AJE, Feng S, Khayyo S, Hinnah K, Li-Purcell N, Pan G, Williams BM, Riezman H, Atilla-Gokcumen GE, Holthuis JCM, Trauner D (2021) ACS Chem Biol  16(3):452-456.

 A three-dimensional model of the yeast transmembrane sensor Wsc1 obtained by SMA-based detergent-free purification and transmission electron microscopy

Voskoboynikova N, Karlova M, Kurre R, Mulkidjanian AY, Shaitan KV, Sokolova OS, Steinhoff HJ, Heinisch JJ (2021) J Fungi (Basel)  7(2):118.

 Zn²⁺ intoxication of Mycobacterium marinum during Dictyostelium discoideum infection Is counteracted by induction of the pathogen Zn²⁺ Exporter CtpC

Hanna N, Koliwer-Brandl H, Lefrançois LH, Kalinina V, Cardenal-Muñoz E, Appiah J, Leuba F, Gueho A, Hilbi H, Soldati T, Barisch C (2021) mBio 12(1):e01313-20.

 Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

Füllbrunn N, Li Z, Jorde L, Richter CP, Kurre R, Langemeyer L, Yu C, Meyer C, Enderlein J, Ungermann C, Piehler J, You C (2021) Elife  10:e62501.

 Sphingomyelin biosynthesis is essential for phagocytic signaling during Mycobacterium tuberculosis host cell entry

Niekamp P, Guzman G, Leier HC, Rashidfarrokhi A, Richina V, Pott F, Barisch C, Holthuis JCM, Tafesse FG (2021) mBio 12(1):e03141-20.

 TORC1 determines Fab1 lipid kinase function at signaling endosomes and vacuoles

Chen Z, Malia PC, Hatakeyama R, Nicastro R, Hu Z, Péli-Gulli MP, Gao J, Nishimura T, Eskes E, Stefan CJ, Winderickx J, Dengjel J, De Virgilio C, Ungermann C (2021) Curr Biol  31(2):297-309.e8.

 Membrane permeability and its activation energies in dependence on analyte, lipid, and phase type obtained by the fluorescent artificial receptor membrane assay

Nilan M, Collin S, Karmacharya S. Hennig A, Nau WM (2021) ACS Sens  6(1):175-182.

 Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

Cui L, Moraga I, Lerbs T, Van Neste C, Wilmes S, Tsutsumi N, Trotman-Grant AC, Gakovic M, Andrews S, Gotlib J, Darmanis S, Enge M, Quake S, Hitchcock IS, Piehler J, Garcia KC, Wernig G (2021) Proc Natl Acad Sci USA  18(2):e2017849118.

 Capillary stamping of functional materials: parallel additive substrate patterning without ink depletion

Runge M, Hübner H, Grimm A, Manoharan G, Wieczorek R, Philippi M, Harneit W, Meyer C, Enke D, Gallei M, Steinhart M (2021) Advanced Materials Interfaces 8:2001911.

 Interaction of Cucurbit[7]uril with protease substrates: application to nanosecond time-resolved fluorescence assays

Hennig A, Nau WM (2020) Front Chem 8:806.

 Parallelized manipulation of adherent living cells by magnetic nanoparticles-mediated forces

Bongaerts M, Aizel K, Secret E, Jan A, Nahar T, Raudzus F, Neumann S, Telling N, Heumann R, Siaugue JM, Menager C, Fresnais J, Villard C, El Haj A, Piehler J, Gates MA, Coppey M (2020) International journal of molecular sciences 21(18):6560.

 Na_1.5-x/2Sr_xGd_1.5-x/2F₆ nanocrystals (0 ≤ x ≤ 1): growth, size control and shell formation on β-NaCeF₄:Tb core particles

Wehmeier J, Haase M (2020) CrystEngComm  22:8036-8044.

 Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

Gorby C, Sotolongo Bellon J, Wilmes S, Warda W, Pohler E, Fyfe PK, Cozzani A, Ferrand C, Walter MR, Mitra S, Piehler J, Moraga I (2020) Sci Signal  13:649.

 Towards a mathematical model for single molecule structured illumination microscopy

Hockmann M, Kunis S, Kurre R (2020) Proc Appl Math Mech 20(1).

 Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex

Gao J, Kurre R, Rose J, Walter S, Fröhlich F, Piehler J, Reggiori F, Ungermann C (2020) EMBO Rep e50733.

 Magnetic and electronic properties of highly Mn-doped β-NaGdF₄ and β-NaEuF₄ nanoparticles with a narrow size distribution

Schneider L, Wehmeier J, Wiedwald U, Rodewald J, Galakhov VR, Udintseva MS, Mesilov V, Radu F, Luo C, Klare JP, Steinhoff H-J, Haase M, Kuepper K J Phys Chem C 124, 33, 18194–18202.

 On the condition number of Vandermonde matrices with pairs of nearly-colliding nodes

Kunis S, Nagel D (2020) Numer Algor  87:473–496.

 On the smallest singular value of multivariate Vandermonde matrices with clustered nodes

Kunis S, Nagel D (2020) Linear Algebra Appl  604:1-20.

 Size-controlled growth of β-NaGdF₄ and β-NaGdF₄:Yb,Er nanocrystals: The influence of the surface area of NaF on the nucleation of the β-phase

Czerny J, Heil F, Egbers CJ, Haase M (2020) Chemistry of Materials  32(13):5691-5699.

 Heme binding of transmembrane signaling proteins undergoing regulated intramembrane proteolysis

Kupke T, Klare JP, Brügger B (2020) Commun Biol  3(1):73.

 Learning algebraic decompositions using Prony structures

Kunis S, Römer T, von der Ohe U (2020) Adv in Appl Math  118:102044.

 LiYF₄:Yb/LiYF₄: and LiYF₄:Yb,Er/LiYF₄: core/shell nanocrystals with luminescence decay times similar to YLF laser crystals and the upconversion quantum yield of the Yb,Er doped nanocrystals

Carl F, Birk L, Grauel B, Pons M, Würth C, Resch-Genger U, Haase M (2020) Nano Research 14:797–806.

 A conserved and regulated mechanism drives endosomal Rab transition

Langemeyer L, Borchers AC, Herrmann E, Füllbrunn N, Han Y, Perz A, Auffarth K, Kümmel D, Ungermann C (2020) Elife  9:e56090.

 Time‐resolved nonlinear diffuse fs‐pulse reflectometry using lithium niobate nanoparticles with two pulses of different colors

Kijatkin C, Bourdon B, Klenen J, Kocsor L, Szaller Z, Imlau M (2020) Adv Photonics Res 2(7).

 Dual-color 3D-dSTORM colocalization and quantification of ROXY1 and RNAPII variants throughout the transcription cycle in root meristem nuclei

Maß L, Holtmannspötter M, Zachgo S (2020) Plant J  104(5):1423-1436.

 The role of cations in hydrothermal synthesis of nonlinear optical sodium niobate nanocrystals

Kohlenbach ND, Kijatkin C, König M, Haase M, Imlau M, Kömpe K (2020) Nanoscale  12:19223-19229.

 AP‐3 vesicle uncoating occurs after HOPS‐dependent vacuole tethering

Schoppe J, Mari M, Yavavli E, Auffarth K, Cabrera M, Walter S, Fröhlich F, Ungermann C (2020) EMBO J  39:e105117.

 Next-generation surrogate Wnts support organoid growth and deconvolute frizzled pleiotropy in vivo

Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC (2020) Cell Stem Cell   S1934-5909(20)30358-1.

 In cellulo protein semi‐synthesis from endogenous and exogenous fragments using the ultra‐fast split Gp41‐1 intein

Bhagawati M, Hoffmann S, Höffgen KS, Piehler J, Busch K, Mootz HD (2020) Angew. Chem. Int. Ed 59:21007.

 In cell Gd³⁺-based site-directed spin labeling and EPR spectroscopy of eGFP

Kucher S, Korneev S, Klare JP, Klose D, Steinhoff HJ (2020) Phys Chem Chem Phys  24(22):13358-13362.

 Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor

Ponsford AH, Ryan TA, Raimondi A, Cocucci E, Wycislo SA, Fröhlich F, Swan LE, Stagi M (2020) Autophagy  17(6):1500–1518.

 Lipid dynamics in nanoparticles formed by maleic acid-containing copolymers: EPR spectroscopy and molecular dynamics simulations

Colbasevici A, Voskoboynikova N, Orekhov PS, Bozdaganyan ME, Karlova MG, Sokolova OS, Klare JP, Mulkidjanian AY, Shaitan KV, Steinhoff HJ (2020)Biochim Biophys Acta Biomembr  1862(5):183207.

 Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae

Esch BM, Limar S, Bogdanowski A, Gournas C, More T, Sundag C, Walter S, Heinisch JJ, Ejsing CS, André B, Fröhlich F (2020) PLoS Genet  16(8):e1008745.

 A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function

Dehnen L, Janz M, Verma JK, Psathaki OE, Langemeyer L, Fröhlich F, Heinisch JJ, Meyer H, Ungermann C, Paululat A (2020) Journal of Cell Science  4133(13):jcs247080.

 The spatio-temporal organization of mitochondrial F₁F₀ ATP synthase in cristae depends on its activity mode

Salewskij K, Rieger B, Hager F, Arroum T, Duwe P, Villalta J, Colgiati S, Richter CP, Psathaki OE, Enriquez JA, Dellmann T, Busch KB (2020) Biochim Biophys Acta Bioenerg  1861(1):148091.

 A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella

Kehl A, Göser V, Reuter T, Liss V, Franke M , John C, Richter CP, Deiwick J, Hensel M (2020) PLoS Pathog  16(7):e1008220.

 Novel fluorescent mitochondria-targeted probe MitoCLox reports lipid peroxidation in response to oxidative stress in vivo

Lyamzaev KG, Panteleeva AA, Karpukhina AA, Galkin II, Popova EN, Pletjushkina OY, Rieger B, Busch KB, Mulkidjanian AY, Chernyak BV (2020) Oxid Med Cell Longev  3631272.

 Self-assembly of robust gold nanoparticle monolayer architectures for quantitative protein interaction analysis by LSPR spectroscopy

Flesch J, Kappen M, Drees C, You C, Piehler J (2020) Analytical and Bioanalytical Chemistr   412:3413–3422.

 Type I IFN is siloed in endosomes

Altman JB, Taft J, Wedeking T, Gruber CN, Holtmannspötter M, Piehler J, and Bogunovic D, (2020) PNAS  30:17510-17512.

 Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes S, Hafer M, Vuorio J, Tucker JA, Winkelmann H, Löchte S, Stanly TA, Pulgar Prieto KD , Poojari C, Sharma V, Richter CP, Kurre R, Hubbard SR, Garcia KC, Moraga I, Vattulainen I, Hitchcock IS, Piehler J (2020) Science 367(6478):643-652.

 Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

Martinez-Fabregas J, Wilmes S, Wang L, Hafer M, Pohler E, Lokau J, Garbers C, Cozzani A, Fyfe PK, Piehler J, Kazemian M, Mitra S, Moraga I (2019) Elife 8:e49314.

 Prony's method on the sphere

Kunis S, Möller HM, and von der Ohe U (2019) SMAI J Comput Math 5S, 87-97.

 Structure of the IFNγ receptor complex guides design of biased agonists

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC (2019) Nature 567(7746):56-60.

 A randomized multivariate matrix pencil method for superresolution microscopy

Ehler M, Kunis S, Peter T, and Richter C (2019) Electron Trans Numer Anal 51:63-74.

 MpTCP1 controls cell proliferation and redox processes in Marchantia polymorpha

Busch A, Deckena M, Almeida-Trapp M, Kopischke S, Kock C, Schüssler E, Tsiantis M, Mithöfer A, Zachgo S (2019) New Phytol  224(4):1627-1641.

 Close-packed silane nanodot arrays by capillary nanostamping coupled with heterocyclic silane ring opening

Philippi M, You C, Richter CP, Schmidt M, Thien J, Liße D, Wollschlager J, Piehler J and Steinhart M (2019) RSC Adv  9:24742.

 Blocks in tricarboxylic acid cycle of salmonella enterica cause global perturbation of carbon storage, motility, and host-pathogen interaction

Noster J, Hansmeier N, Persicke M, Chao TC, Kurre R, Popp J, Liss V, Reuter T, Hensel M (2019) mSphere 4(6):e00796-19.

 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis

Mohan K, Ueda G, Kim AR, Jude KM, Fallas JA, Guo Y, Hafer M, Miao Y, Saxton RA, Piehler J, Sankaran VG, Baker D, Garcia KC (2019) Science 364(6442):eaav7532.

 MitoCLox: A novel mitochondria-targeted fluorescent probe for tracing lipid peroxidation

Konstantin G, Lyamzaev KG, Sumbatyan NV, Nesterenko AM, Kholina EG, Voskoboynikova N, Steinhoff H-J, Mulkidjanian AY (2019) Oxid Med Cell Longev  9710208.

 ESEEM reveals bound substrate histidine in the ABC transporter HisQMP₂

Isaev N, Heuveling J, Ivanisenko N, Schneider E, Steinhoff HJ (2019) Applied Magnetic Resonance  1-11.

 Conformational dynamics of sensory rhodopsin II in nanolipoprotein and styrene-maleic acid lipid particles

Mosslehy W, Voskoboynikova N, Colbasevici A, Ricke A, Klose D, Klare JP, Mulkidzhanyan AY, Steinhoff HJ (2019) Photochem Photobiol.

 Proton leakage across lipid bilayers: Oxygen atoms of phospholipid ester linkers align water molecules into transmembrane water wires

Bozdaganyan ME, Lokhmatikov AV, Voskoboynikova N, Cherepanov DA, Steinhoff HJ, Shaitan KV, Mulkidjanian AY (2019) BBA-Bioenergetics 1860(6):439-451.

 Styrene/maleic acid copolymers form SMALPs by pulling lipid patches out of the lipid bilayer

Orekhov PS, Bozdaganyan ME, Voskoboynikova N, Mulkidjanian AY, Steinhoff HJ, Shaitan KV (2019) Langmuir  35(10):3748-3758.

 Detergent-free solubilization of human Kv channels expressed in mammalian cells

Karlova MG, Voskoboynikova N, Gluhov GS, Abramochkin D, Malak OA, Mulkidzhanyan A, Loussouarn G, Steinhoff HJ, Shaitan KV, Sokolova OS (2019) Chem Phys Lipids 219.

 Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

Kol M, Williams B, Toombs-Ruane H, Franquelim HG, Korneev S, Schroeer C, Schwille P, Trauner D, Holthuis JC, Frank JA (2019) Elife, 8:e43230.

 Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

Pekkinen M, Terhal PA, Botto LD, Henning P, Mäkitie RE, Roschger P, Jain A, Kol M, Kjellberg MA, Paschalis EP, van Gassen K, Murray M, Bayrak-Toydemir P, Magnusson MK, Jans J, Kausar M, Carey JC, Somerharju P, Lerner UH, Olkkonen VM, Klaushofer K, Holthuis JC, Mäkitie O (2019) JCI Insight  4(7):e126180. 

 Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Dadsena S, Bockelmann S, Mina JGM, Hassan DG, Korneev S, Razzera G, Jahn H, Niekamp P, Müller D, Schneider M, Tafesse FG, Marrink SJ, Melo MN, Holthuis JCM (2019) Nat Commun 10(1).

 A systematic approach to identify recycling endocytic cargo depending on the GARP complex

Eising S, Thiele L, Fröhlich F (2019) eLife  8:e42837.

 Annexins A2 and A6 interact with the extreme N terminus of tau and thereby contribute to tau's axonal localization

Gauthier-Kemper A, Suárez Alonso M, Sündermann F, Niewidok B, Fernandez MP, Bakota L, Heinisch JJ, Brandt R (2018) J Biol Chem  25;293(21):8065-8076.

 Identification and in vivo characterisation of cardioactive peptides in Drosophila melanogaster

Schiemann R, Lammers K, Janz M, Lohmann J, Paululat A, Meyer H (2018) Int J Mol Sci. 20(1):2.

 SERCA is critical to control the Bowditch effect in the heart

Balcazar D, Regge V, Santalla M, Meyer H, Paululat A, Mattiazzi A, Ferrero P (2018) Sci Rep  8:12447.

 APC/CFzr regulates cardiac and myoblast cell numbers, and plays a crucial role during myoblast fusion

Drechsler M, Meyer H, Wilmes AC, Paululat A (2018) J Cell Sci  131(14):jcs209155.

 Drosophila pericardial nephrocyte ultrastructure changes during ageing

Psathaki OE, Dehnen L, Hartley PS, Paululat A (2018) Mech Ageing Dev  173:9-20.

 Multi-color localization microscopy of single membrane proteins in organelles of live mammalian cells

Appelhans T, Beinlich FRM, Richter CP, Kurre R, Busch KB (2018) J Vis Exp  136:57690.

 Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules

Niewidok B, Igaev M, Pereira da Graca A, Strassner A, Lenzen C, Richter CP, Piehler J, Kurre R, Brandt R (2018) J Cell Biol, 217:1303-1318.

 Stable and selective self-assembly of α-lipoic acid on Ge(001) for biomolecule immobilization

Kazmierczak M, Flesch J, Mitzloff J, Capellini G, Klesse WM, Skibitzki O, You C, Bettenhausen M, Witzigmann B, Piehler J, Schroeder T, Guha S (2018) Journal of Applied Physics  123:175305.

 Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells

Etoc F, Balloul E, Vicario C, Normanno D, Liße D, Sittner A, Piehler J, Dahan M, Coppey M (2018) Nature materials  17:740-746.

 How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Chavent M, Duncan AL, Rassam P, Birkholz O, Hélie J, Reddy T, Beliaev D, Hambly B, Piehler J, Kleanthous C, Sansom MSP (2018) Nat Commun  9:2846.

 Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials

Birkholz O, Burns JR, Richter CP, Psathaki OE, Howorka S, Piehler J (2018) Nat Commun  9:1521.

 Germanium plasmon enhanced resonators for label-free terahertz protein sensing

Bettenhausen M, Römer F, Witzigmann B, Flesch J, Kurre R, Korneev S, Piehler J, You C, Kazmierczak M, Guha S, Capellini G, Schröder T (2018) Frequenz, 72, 113-122.

 Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis

Bartoschik T, Galinec S, Kleusch C, Walkiewicz K, Breitsprecher D, Weigert S, Muller YA, You C, Piehler J, Vercruysse T, Daelemans D, Tschammer N (2018) Scientific reports  8:4977.

 A search for ceramide binding proteins using bifunctional lipid analogues yields CERT-related protein StarD7

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Müller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, and Holthuis JC (2018) J Lipid Res  59:515-530.

 Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants

Kunduri G, Turner-Evans D, Konya Y, Izumi Y, Nagashima K, Lockett S, Holthuis J, Bamba T, Acharya U, Acharya JK (2018) Proc Natl Acad Sci USA  115:E8919-E8928.

 Colloidal crystals of NaYF₄ upconversion nanocrystals studied by small-angle X-ray scattering (SAXS)

Homann C, Bolze J, Haase M (2018) Part Part Syst Charact  1800391.

 Colloidal LaPO₄:Gd³⁺ nanocrystals: X-ray induced single line UV emission

Espinoza S, Juestel T, Haase M (2018) Nanoscale 10:22533-22540. 

 Deep utraviolet emitting scintillators for biomedical applications: The hard way of downsizing LuPO₄:Pr³⁺

Espinoza S, Volhard MF, Kätker H, Jenneboer H, Uckelmann A, Haase M, Müller M , Purschke M, Jüstel T (2018) Part Part Syst Charact  1800282.

 NaYF₄:Yb,Er/NaYF₄ core/shell nanocrystals with high upconversion luminescence quantum yield

Homann C, Krukewitt L, Frenzel F, Grauel B, Würth C , Resch-Genger U, Haase M (2018) Angew Chem Int Ed, 57:8765–8769.

 Holographic performance of silicon polymer films based on photoswitchable molecules

Bourdon B, Bock S, Kijatkin C, Shumelyuk A, Imlau M (2018) Optical Material Express 8(7):1951-1967.

 Nonlinear optical potassium niobate nanocrystals as harmonic markers: the role of precursors and stoichiometry in hydrothermal synthesis

Wang Z, Kijatkin C, Urban A, Haase M, Imlau M, Kömpe K (2018) Nanoscale, 10:10713-10720.

 Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

Richter D, Moraga I, Winkelmann H, Birkholz O, Wilmes S, Schulte M, Kraich M, Kenneweg H, Beutel O, Selenschik P, Paterok D, Gavutis M, Schmidt T, Garcia KC, Müller TD, Piehler J (2017) Nat Commun  8:15976.

 Magnetic control of cellular processes using biofunctional nanoparticles

Monzel C, Vicario C, Piehler J, Coppey M, Dahan M (2017) Chemical science  8:7330-7338.

 Engineered ferritin for magnetogenetic manipulation of proteins and organelles inside living cells

Liße D, Monzel C, Vicario C, Manzi J, Maurin I, Coppey M, Piehler J, Dahan M (2017) Advanced materials  29:1700189.

 Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC (2017) Nature  545:234-237.

 Binding of interferon reduces the force of unfolding for interferon receptor 1

Chuartzman SG, Nevo R, Waichman S, Shental D, Piehler J, Levy Y, Reich Z, Kapon R (2017) PLoS One  12:e0175413.

 STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Arimoto KI, Löchte S, Stoner SA, Burkart C, Zhang Y, Miyauchi S, Wilmes S, Fan JB, Heinisch JJ, Li Z, Yan M, Pellegrini S, Colland F, Piehler J, Zhang DE (2017) Nature structural & molecular biology  24:279-289.

 ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

Cabukusta B, Kol M, Kneller L, Hilderink A, Bickert A, Mina JG, Korneev S, Holthuis JC  (2017) Sci Rep  7:41290.

 Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

Jain A, Beutel O, Ebell K, Korneev S, and Holthuis JC (2017) J Cell Sci  130:360-371.

 Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JGM, Somerharju P, Korneev S, Tafesse FG, and Holthuis JC (2017) J Lipid Res  58:962-973.

 Nonlinear diffuse fs-pulse reflectometry of harmonic upconversion nanoparticles

Kijatkin C, Eggert J, Bock S, Berben D, Oláh L, Szaller Z, Kis Z and Imlau M (2017) Photonics  4(1):11.

 Drosophila neprilysins control insulin signaling and food intake via cleavage of regulatory peptides

Hallier B, Schiemann R, Cordes E, Vitos-Faleato J, Walter S, Heinisch JJ, Malmendal A, Paululat A, Meyer H (2016) Elife  5:e19430.

 Monitoring changes in the oligomeric state of a candidate endoplasmic reticulum (ER) ceramide sensor by single-molecule photobleaching

Cabukusta B, Köhlen JA, Richter CP, You C, Holthuis JC (2016) J Biol Chem  291(47):24735–24746.

 Functional protein micropatterning for drug design and discovery

You, C, and Piehler, J (2016) Expert opinion on drug discovery  11:105-119.

 Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling

You C, Marquez-Lago TT, Richter CP, Wilmes S, Moraga I, Garcia KC, Leier A, Piehler J (2016) Science advances  2:e1600452.

 Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing

Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, Kaur P, Miao W, Gurgel G, You C, Piehler J, Kad NM, Riehn R, Opresko PL, Smith S, Tao YJ, Wang H (2016) Nucleic acids research  44:6363-6376.

 Bioinspired monolithic polymer microsphere arrays as generically anti-adhesive surfaces

Eichler-Volf A, Kovalev A, Wedeking T, Gorb EV, Xue L, You C, Piehler J, Gorb SN, Steinhart M (2016) Bioinspiration & biomimetics  11:025002.

 Engineered upconversion nanoparticles for resolving protein interactions inside living cells

Drees C, Raj AN, Kurre R, Busch KB, Haase M, Piehler J (2016) Angew Chem Int Ed Engl  55:11668-11672.

 Single molecule super-resolution imaging of proteins in living Salmonella enterica using self-labelling enzymes

Barlag B, Beutel O, Janning D, Czarniak F, Richter CP, Kommnick C, Göser V, Kurre R, Fabiani F, Erhardt M, Piehler J, Hensel M (2016) Scientific reports  6:31601.

 Structure of the tuberous sclerosis complex 2 (TSC2) N terminus provides insight into complex assembly and tuberous sclerosis pathogenesis 

Zech R, Kiontke S, Mueller U, Oeckinghaus A, Kümmel D (2016) J Biol Chem  291:20008.

 The N-terminus of the floral Arabidopsis TGA transcription factor PERIANTHIA mediates redox-sensitive DNA-binding

Gutsche N and Zachgo S (2016) PlosOne 29  11(4):e0153810.